| 马晓璐,魏莉,陈波斌,陈勤奋.大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤的观察与护理[J].上海护理,2014,14(7): |
| 大剂量甲氨蝶呤治疗原发性中枢神经系统淋巴瘤的观察与护理 |
| Observation and nursing care of patients with primary central nervous system lymphoma treated by high-dose methotrexate (Huashan Hospital, Fudan University, Shanghai 200040, China)MA Xiao-lu, WEI Li, CHEN Bo-bin, CHEN Qin-fen. |
| 投稿时间：2013-02-18 修订日期：2013-05-29 |
| DOI： |
| 中文关键词: 原发性中枢神经系统淋巴瘤 大剂量甲氨蝶呤 观察 护理 |
| 英文关键词:Primary Central Nervous System Lymphoma high-dose methotrexate Observation Nursing Care |
| 基金项目:上海市卫生局科研基金（2008064）、上海市自然科学基金（10ZR1405200） |
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| 中文摘要: |
| 目的 探讨大剂量甲氨蝶呤(HD-MTX)治疗原发性中枢神经系统淋巴瘤(PCNSL)的观察与护理方法。方法 选择2011年1月—2012年6月收治的PCNSL患者27例,通过心理护理、用药护理和不良反应护理协助其顺利完成HD-MTX治疗。结果 27例PCNSL患者共完成130次HD-MTX化疗,部分患者出现Ⅰ～Ⅱ度的骨髓抑制、黏膜溃疡和消化道毒性,均在对症处理后获得缓解。结论 HD-MTX是治疗PCNSL的重要措施,但不良反应常见,严重时可致死。有效的护理干预可减轻HD-MTX引起的毒副作用,帮助患者顺利度过化疗期,提高疗效,延长生存。 |
| 英文摘要: |
| Objective To study the approach of observation and nursing care for high-dose methothrexate(HD-MTX) in primary central nervous system lymphoma(PCNSL) patients. Methods 27 PCNSL patients were selected from January 2011 to June 2012. They finished HD-MTX chemotherapy by the help of mental nursing, medication nursing and adverse reaction nursing. Results 27 cases finished 130 times HD-MTX chemotherapy. Some patients appeared Ⅰ～Ⅱ degree bone marrow suppression, mucous membrane ulcer and gastrointestinal toxicity. They recovered after symptomatic treatment. Conclusion HD-MTX is an important therapeutics, but has many adverse reactions, even causing death. Effective nursing care can help to reduce the toxic and side-effect of HD-MTX, help patients to finish the chemotherapy, and help them to improve the prognosis. |
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