| 郝子兰[],李岩,刘云肖,李晓荟.妇科恶性肿瘤患者并发静脉血栓栓塞风险预测模型的系统评价[J].上海护理,2024,24(5): |
| 妇科恶性肿瘤患者并发静脉血栓栓塞风险预测模型的系统评价 |
| Prediction models for Gynecological tumor complicated by venous thromboembolism: a systematic review |
| 投稿时间：2023-08-06 修订日期：2024-05-11 |
| DOI： |
| 中文关键词: 妇科恶性肿瘤 静脉血栓 风险预测 模型 系统评价 |
| 英文关键词: |
| 基金项目:河北省中医药康养照护研究重点实验室项目(项目SZX2021025) |
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| 中文摘要: |
| 目的 通过系统评价妇科恶性肿瘤患者并发静脉血栓栓塞(VTE)风险预测模型,以期为妇科恶性肿瘤患者发生VTE防治和模型的开发提供循证参考。方法 检索中英文数据库关于妇科恶性肿瘤合并VTE风险预测模型构建的研究,检索时限自建库至2023年4月。对纳入文献进行筛选、资料提取,采用预测模型研究的偏倚风险适用性评估工具进行文献质量评价。结果 共纳入模型构建研究10个,建立模型的曲线下面积(AUC)为0.722~0.929,验证模型的AUC为0.810~0.911,其中候选预测因子数量为10~36个,纳入模型最多的预测因子为D-二聚体、年龄、BMI、手术时间、输血史。纳入研究均存在高风险偏倚,在各领域适用性较好。结论 妇科恶性肿瘤并发VTE风险预测模型处于发展阶段,未来在模型构建中可按照PROBAST工具相关条目开展。D-二聚体、年龄、BMI、手术时间、输血史为妇科恶性肿瘤患者并发VTE高风险因素,医护人员应积极应对存在以上危险因素的高危患者,以降低VTE发生率。 |
| 英文摘要: |
| Objective To systematically review the risk prediction model of venous thromboembolism in patients with gynecological malignant tumors, in order to provide evidence-based reference for the prevention and development of VTE prevention and model in patients with gynecological malignant tumors. Methods We searched Chinese and English databases on the construction of risk prediction model for gynecological malignant tumors combined with VTE, and the search time limit was self-established until April 2023. The included literature was screened and data extracted, and PROBAST was used for literature quality evaluation. Results A total of 10 model construction studies were included, the area under the curve of the model was 0.722~0.929, the AUC of the verified model was 0.810~0.911, the number of candidate predictors was 10~36, and the most predictors included in the model were D-dimer, age, BMI, operation time, and blood transfusion history. The included studies were at high risk of bias and were well applicable in all domains. Conclusion The risk prediction model of VTE complicated by gynecological malignant tumor is in the development stage, and the relevant items of PROBAST can be carried out in the model construction in the future. D-dimer, age, BMI, operation time, and blood transfusion history are high-risk factors for patients with gynecological malignant tumors complicated by VTE, and medical staff should actively respond to high-risk patients with the above risk factors to reduce the incidence of VTE. |
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