药物性肝损伤患者药物素养研究现状
Research Status of Medication Literacy in Patients with Drug-Induced Liver Injury
投稿时间:2026-03-14  修订日期:2026-06-21
DOI:
中文关键词:  药物性肝损伤  药物素养  健康教育  综述
英文关键词:drug-induced liver injury  medication literacy  health education  review
基金项目:深圳市“医疗卫生三名工程”项目资助(SZZYSM202311014)
作者单位邮编
卢楚雯 广州中医药大学第七临床医学院 518100
尹昊冉 广州中医药大学第七临床医学院 518100
甘苗 广州中医药大学第七临床医学院 518100
张惠珍* 广东省深圳市宝安区中医院 518100
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中文摘要:
      药物性肝损伤是由化学药物、中成药、中药材、天然药物、保健品及膳食补充剂等引起的肝损伤。我国DILI患者具有致病因素来源广泛和用药情境复杂特点,患者在疾病管理过程中常存在风险认知不足、自行用药、用药信息报告不充分及随访依从性较差等问题。药物素养是患者获取、理解、评估和应用药物信息并作出安全用药决策的重要能力,对药物性肝损伤的早期识别、再暴露预防和长期管理具有重要意义。本文从药物素养的概念内涵、问题表现、影响因素、评估工具及教育干预等方面进行综述。现有研究提示,药物性肝损伤患者药物素养研究仍存在专病评估工具缺乏、干预内容标准化不足、长期随访和再暴露预防关注不够等问题。未来应结合我国中西药联用及中草药使用背景,开发适用于药物性肝损伤患者的药物素养评估工具,构建涵盖药物素养各维度的标准化教育方案,为临床实施全程化药物安全管理提供参考。
英文摘要:
      Drug-induced liver injury (DILI) is hepatic damage caused by chemical drugs, Chinese patent medicines, Chinese medicinal materials, natural medicines, health products, and dietary supplements. In China, DILI is characterized by diverse etiological sources and complex medication exposure scenarios, and patients often exhibit insufficient risk awareness, self-medication behaviors, incomplete reporting of medication information, and poor adherence to follow-up during disease management. Medication literacy refers to patients’ ability to acquire, understand, evaluate, and apply medication-related information to make safe medication decisions, which is important for early identification, prevention of re-exposure, and long-term management of DILI. This review summarizes the concept, problematic manifestations, influencing factors, assessment tools, and educational interventions related to medication literacy in patients with DILI. Future research should develop disease-specific medication literacy assessment tools and standardized educational programs based on the Chinese medication-use context, so as to provide a reference for precise and continuous medication safety management in clinical practice.
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