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| 癌症患者经济毒性纵向研究的范围综述 |
| A Scoping Review of Longitudinal Studies on Financial Toxicity in Cancer Patients |
| 投稿时间：2026-04-21 修订日期：2026-06-21 |
| DOI： |
| 中文关键词: 癌症患者 主观经济毒性 客观经济毒性 纵向研究 护理 |
| 英文关键词:Cancer patients Subjective financial toxicity Objective financial toxicity Longitudinal study Nursing |
| 基金项目: |
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| 中文摘要: |
| 【】目的:对癌症患者经济毒性纵向研究进行范围综述,明确患者经济毒性的测量时间、评估工具、变化趋势及影响因素,为今后开展相关护理研究和实践提供参考。方法:依据范围综述指南为方法框架,系统检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库,PubMed、Web of Science、CINAHL、Cochrane Library、Embase等数据库,检索时限为建库至2026年2月26日。由2名研究人员独立筛选文献、提取数据,并进行JBI质量评价及内容汇总分析。结果:共纳入36篇文献,其中主观经济毒性26篇,客观经济毒性12篇,2篇同时报告了主观和客观经济毒性。覆盖9个国家,研究对象包含多种癌症。高频测量时间点为治疗后1、3、6、12、24个月。主观经济毒性评估工具9种,最多选用的是综合经济毒性评分量表(Comprehensive Score for Financial Toxicity,COST)及其汉化版；客观经济毒性缺乏标准化评估工具,多采用医疗费用、收入变化、就业状态等量化指标表征。癌症患者经济毒性变化存在多种轨迹特征。癌症患者的经济毒性受患者个体特征因素、疾病与治疗相关因素、社会经济与支持因素及健康相关心理与行为因素影响,主观与客观经济毒性的影响因素具有共性,主观经济毒性额外受更多心理与行为相关因素影响。结论:癌症患者经济毒性纵向研究存在研究不足,国内本土化特异性工具有待进一步探讨。癌症患者经济毒性变化趋势存在癌种、地区及群体异质性,其影响因素在主客观维度兼具共性与特异性。未来需要深化影响因素的纵向研究,优化评估工具与研究设计,为构建针对性护理干预方案、缓解患者经济毒性提供循证依据。 |
| 英文摘要: |
| Objective: To conduct a scoping review on longitudinal studies of financial toxicity in cancer patients, clarify the measurement time points, assessment tools, changing trends and influencing factors of patients" financial toxicity, so as to provide references for relevant nursing research and practice in the future. Methods: Following the methodological framework of scoping review guidelines, systematic searches were performed in databases including CNKI, CBM, Wanfang, VIP, PubMed, Web of Science, CINAHL, Cochrane Library and Embase, with the retrieval period from inception to February 26, 2026. Two researchers independently screened literature, extracted data, and conducted JBI quality assessment and content summary analysis. Results: A total of 36 articles were included, among which 26 focused on subjective financial toxicity, 12 on objective financial toxicity, and 2 reported both subjective and objective financial toxicity. The studies covered 9 countries and included patients with various types of cancer. The high-frequency measurement time points were 1, 3, 6, 12 and 24 months after treatment. Nine assessment tools were used for subjective financial toxicity, among which the Comprehensive Score for Financial Toxicity (COST) and its Chinese version were the most commonly adopted. There was a lack of standardized assessment tools for objective financial toxicity, which was mostly characterized by quantitative indicators such as medical expenses, income changes and employment status. The changes in financial toxicity of cancer patients presented multiple trajectory characteristics. Financial toxicity in cancer patients was affected by individual patient characteristics, disease and treatment-related factors, socioeconomic and support factors, as well as health-related psychological and behavioral factors. Influencing factors of subjective and objective financial toxicity shared commonalities, while subjective financial toxicity was additionally affected by more psychological and behavioral factors. Conclusions: Longitudinal studies on financial toxicity in cancer patients are insufficient, and localized and specific assessment tools in China need to be further explored. The changing trends of financial toxicity in cancer patients are heterogeneous across cancer types, regions and populations, and its influencing factors have both commonalities and specificities in subjective and objective dimensions. In the future, it is necessary to deepen longitudinal research on influencing factors, optimize assessment tools and research designs, so as to provide evidence-based basis for developing targeted nursing intervention programs and alleviating financial toxicity in patients. |
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